This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:217,943,677–217,944,438 | 273.0 kb | Distal (>10kb) Multiome | 486 | |
| chr2:217,978,332–217,979,228 | 238.4 kb | Distal (>10kb) Multiome | 246 | |
| chr2:217,987,861–217,989,008 | 228.7 kb | Distal (>10kb) Multiome | 528 | |
| chr2:218,033,728–218,035,208 | 182.3 kb | Distal (>10kb) Multiome | 270 | |
| chr2:218,068,640–218,069,336 | 148.2 kb | Distal (>10kb) Multiome | 187 | |
| chr2:218,216,755–218,218,281 | 36 bp | At TSS Multiome | 875 | |
| chr2:218,269,385–218,270,929 | 53.2 kb | Distal (>10kb) Multiome | 913 | |
| chr2:218,290,037–218,290,611 | 73.1 kb | Distal (>10kb) Multiome | 264 | |
| chr2:218,291,910–218,292,722 | 75.4 kb | Distal (>10kb) Multiome | 695 | |
| chr2:218,322,154–218,324,454 | 106.0 kb | Distal (>10kb) Multiome | 914 | |
| chr2:218,367,421–218,368,194 | 150.7 kb | Distal (>10kb) Multiome | 450 | |
| chr2:218,387,091–218,388,220 | 170.8 kb | Distal (>10kb) Multiome | 514 | |
| chr2:218,395,568–218,397,399 | 179.1 kb | Distal (>10kb) Multiome | 1048 | |
| chr2:218,397,484–218,401,433 | 180.8 kb | Distal (>10kb) Multiome | 1114 | |
| chr2:218,405,424–218,407,478 | 189.3 kb | Distal (>10kb) Multiome | 1093 |
Genomic view of the ARPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.