The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ARMC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,785,146–18,785,600 | 248.2 kb | Distal (>10kb) Multiome | 247 | |
| chr19:18,831,386–18,833,070 | 201.7 kb | Distal (>10kb) Multiome | 833 | |
| chr19:18,870,063–18,870,526 | 163.1 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 137.4 kb | Distal (>10kb) Multiome | 554 | |
| chr19:18,918,971–18,919,972 | 114.0 kb | Distal (>10kb) Multiome | 828 | |
| chr19:18,932,038–18,933,012 | 101.1 kb | Distal (>10kb) Multiome | 312 | |
| chr19:18,940,835–18,941,417 | 92.3 kb | Distal (>10kb) Multiome | 336 | |
| chr19:19,017,061–19,017,561 | 16.3 kb | Distal (>10kb) Multiome | 21 | |
| chr19:19,032,381–19,032,727 | 856 bp | At TSS | 254 | |
| chr19:19,032,820–19,034,059 | 108 bp | At TSS Multiome | 944 | |
| chr19:19,034,180–19,034,559 | 596 bp | At TSS | 427 | |
| chr19:19,063,253–19,064,386 | 30.2 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 72.1 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 77.1 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 87.0 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 104.9 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 136.8 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 159.0 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 169.9 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 191.6 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 228.1 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 239.6 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 287.1 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the ARMC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.