Enables G protein activity; guanyl ribonucleotide binding activity; and tubulin binding activity. Involved in several processes, including antigen processing and presentation following phagocytosis; cytosolic transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Is active in early endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARL8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:4,867,666–4,869,297 | 253.8 kb | Distal (>10kb) Multiome | 812 | |
| chr3:4,975,994–4,976,641 | 146.0 kb | Distal (>10kb) Multiome | 525 | |
| chr3:4,976,933–4,980,833 | 143.3 kb | Distal (>10kb) Multiome | 1341 | |
| chr3:4,985,756–4,987,513 | 136.4 kb | Distal (>10kb) Multiome | 1151 | |
| chr3:5,001,877–5,002,834 | 119.8 kb | Distal (>10kb) Multiome | 452 | |
| chr3:5,016,164–5,017,130 | 105.6 kb | Distal (>10kb) Multiome | 672 | |
| chr3:5,017,970–5,018,615 | 104.0 kb | Distal (>10kb) Multiome | 294 | |
| chr3:5,026,091–5,027,285 | 95.4 kb | Distal (>10kb) Multiome | 782 | |
| chr3:5,122,077–5,123,401 | 673 bp | At TSS Multiome | 1009 | |
| chr3:5,186,712–5,189,316 | 65.3 kb | Distal (>10kb) Multiome | 891 | |
| chr3:5,213,036–5,214,091 | 91.4 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the ARL8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.