ARL8A
ARF like GTPase 8A | FLJ45195, Gie2, ARL10B

Enables GTP binding activity. Predicted to be involved in anterograde axonal transport and chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.17 Developmental clusters: GC6
Biological processes 28 terms
GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)alpha-tubulin binding (GO:0043014)anterograde axonal transport (GO:0008089)anterograde axonal transport (GO:0008089)axon (GO:0030424)axon cytoplasm (GO:1904115)azurophil granule membrane (GO:0035577)beta-tubulin binding (GO:0048487)chromosome segregation (GO:0007059)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)ficolin-1-rich granule membrane (GO:0101003)late endosome membrane (GO:0031902)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)membrane (GO:0016020)midbody (GO:0030496)plasma membrane (GO:0005886)protein binding (GO:0005515)protein transport (GO:0015031)spindle (GO:0005819)spindle midzone (GO:0051233)spindle midzone (GO:0051233)synapse (GO:0045202)
Expression (TPM)
ARL8A — as a Regulated Gene

TFs regulating ARL8A 0 TFs

Transcription factors with Perturb-seq knockdown data for ARL8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ARL8A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:201,888,189–201,889,202 255.9 kb Distal (>10kb) Multiome 335
chr1:201,895,782–201,896,239 248.6 kb Distal (>10kb) Multiome 606
chr1:201,941,439–201,942,399 202.8 kb Distal (>10kb) Multiome 508
chr1:201,946,301–201,946,923 198.1 kb Distal (>10kb) Multiome 290
chr1:201,955,139–201,955,899 189.3 kb Distal (>10kb) Multiome 881
chr1:201,982,248–201,983,657 161.4 kb Distal (>10kb) Multiome 875
chr1:202,007,961–202,008,615 136.4 kb Distal (>10kb) Multiome HiCAR 368
chr1:202,009,428–202,011,367 134.2 kb Distal (>10kb) Multiome 761
chr1:202,075,813–202,076,531 68.6 kb Distal (>10kb) Multiome 418
chr1:202,101,336–202,102,103 42.9 kb Distal (>10kb) Multiome 173
chr1:202,105,597–202,106,270 38.8 kb Distal (>10kb) Multiome 376
chr1:202,135,239–202,135,691 9.3 kb Proximal (<10kb) Multiome 193
chr1:202,143,721–202,144,890 740 bp At TSS Multiome 589
chr1:202,184,705–202,185,268 40.2 kb Distal (>10kb) Multiome 258
chr1:202,214,010–202,214,579 69.6 kb Distal (>10kb) Multiome 215
chr1:202,235,967–202,236,655 91.7 kb Distal (>10kb) Multiome 460
chr1:202,237,030–202,237,425 92.6 kb Distal (>10kb) Multiome 305
chr1:202,341,446–202,342,246 197.3 kb Distal (>10kb) Multiome 728
chr1:202,348,195–202,349,447 203.9 kb Distal (>10kb) Multiome 898

Genome Browser

Genomic view of the ARL8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:201,878,189 – 202,359,447
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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