Enables identical protein binding activity. Predicted to be involved in RNA splicing. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARL6IP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL6IP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL6IP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,751,194–122,751,767 | 228.9 kb | Distal (>10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 227.5 kb | Distal (>10kb) Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 205.7 kb | Distal (>10kb) Multiome | 445 | |
| chr12:122,834,656–122,836,128 | 144.8 kb | Distal (>10kb) Multiome | 514 | |
| chr12:122,895,832–122,896,391 | 84.2 kb | Distal (>10kb) Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 13.7 kb | Distal (>10kb) Multiome | 576 | |
| chr12:122,974,115–122,975,704 | 5.4 kb | Proximal (<10kb) Multiome | 889 | |
| chr12:122,980,138–122,981,155 | 401 bp | At TSS Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 69.6 kb | Distal (>10kb) Multiome | 45 | |
| chr12:123,150,285–123,151,740 | 170.8 kb | Distal (>10kb) Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 252.9 kb | Distal (>10kb) Multiome HiCAR | 1073 | |
| chr12:123,269,375–123,269,864 | 289.4 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 291.0 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the ARL6IP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.