Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARL17A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL17A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL17A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:46,741,863–46,742,381 | 162.4 kb | Distal (>10kb) Multiome | 64 | |
| chr17:46,770,710–46,773,968 | 192.2 kb | Distal (>10kb) Multiome | 1101 | |
| chr17:46,785,507–46,786,271 | 206.3 kb | Distal (>10kb) Multiome | 111 | |
| chr17:46,818,301–46,820,276 | 239.7 kb | Distal (>10kb) Multiome | 471 | |
| chr17:46,820,873–46,822,625 | 242.7 kb | Distal (>10kb) Multiome | 430 | |
| chr17:46,850,945–46,852,297 | 271.8 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the ARL17A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.