The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ARL16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,393,141–81,395,575 | 289.7 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 286.4 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 202.2 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 199.3 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 195.7 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 170.8 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 164.2 kb | Distal (>10kb) Multiome | 617 | |
| chr17:81,537,462–81,537,907 | 146.1 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 130.6 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 46.7 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 35.5 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 30.6 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 17.1 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 152 bp | At TSS Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 19.6 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 28.5 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 149.5 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 177.1 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 184.8 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 187.5 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 208.0 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 227.8 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 234.4 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 239.8 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 244.1 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 253.6 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 276.0 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 284.3 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 293.9 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the ARL16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.