Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in several cellular components, including Lewy body; cullin-RING ubiquitin ligase complex; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARIH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARIH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARIH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:72,184,180–72,184,756 | 289.9 kb | Distal (>10kb) Multiome | 376 | |
| chr15:72,196,452–72,198,720 | 276.4 kb | Distal (>10kb) Multiome | 458 | |
| chr15:72,226,391–72,227,225 | 247.4 kb | Distal (>10kb) Multiome | 515 | |
| chr15:72,229,966–72,232,028 | 243.0 kb | Distal (>10kb) Multiome | 1128 | |
| chr15:72,242,418–72,243,365 | 231.3 kb | Distal (>10kb) Multiome | 236 | |
| chr15:72,271,919–72,273,237 | 201.6 kb | Distal (>10kb) Multiome | 687 | |
| chr15:72,319,497–72,320,675 | 154.3 kb | Distal (>10kb) Multiome | 632 | |
| chr15:72,375,551–72,376,566 | 98.3 kb | Distal (>10kb) Multiome | 1074 | |
| chr15:72,473,670–72,475,497 | 107 bp | At TSS Multiome | 1105 |
Genomic view of the ARIH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.