Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGEF37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:149,264,564–149,265,053 | 287.1 kb | Distal (>10kb) Multiome | 184 | |
| chr5:149,271,306–149,272,588 | 280.1 kb | Distal (>10kb) Multiome | 470 | |
| chr5:149,273,332–149,274,284 | 278.1 kb | Distal (>10kb) Multiome | 77 | |
| chr5:149,344,876–149,346,055 | 206.5 kb | Distal (>10kb) Multiome | 998 | |
| chr5:149,357,500–149,358,624 | 194.0 kb | Distal (>10kb) Multiome | 674 | |
| chr5:149,367,315–149,368,054 | 184.3 kb | Distal (>10kb) Multiome | 450 | |
| chr5:149,371,224–149,371,844 | 180.4 kb | Distal (>10kb) Multiome | 189 | |
| chr5:149,381,769–149,382,370 | 169.9 kb | Distal (>10kb) Multiome HiCAR | 395 | |
| chr5:149,402,230–149,402,797 | 149.5 kb | Distal (>10kb) Multiome | 18 | |
| chr5:149,550,938–149,552,144 | 359 bp | At TSS Multiome | 1038 | |
| chr5:149,581,015–149,581,833 | 29.5 kb | Distal (>10kb) Multiome | 422 | |
| chr5:149,582,081–149,582,491 | 584 bp | At TSS | 187 | |
| chr5:149,729,917–149,732,346 | 178.3 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the ARHGEF37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.