Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for ARHGEF15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:8,015,966–8,016,968 | 294.2 kb | Distal (>10kb) Multiome | 339 | |
| chr17:8,068,609–8,069,844 | 241.4 kb | Distal (>10kb) Multiome | 100 | |
| chr17:8,079,261–8,080,640 | 230.8 kb | Distal (>10kb) Multiome | 613 | |
| chr17:8,109,567–8,110,530 | 200.0 kb | Distal (>10kb) Multiome | 360 | |
| chr17:8,117,780–8,119,396 | 191.3 kb | Distal (>10kb) Multiome | 684 | |
| chr17:8,119,590–8,122,560 | 189.7 kb | Distal (>10kb) Multiome | 968 | |
| chr17:8,125,308–8,126,995 | 184.5 kb | Distal (>10kb) Multiome | 724 | |
| chr17:8,138,425–8,139,804 | 171.3 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,151,026–8,151,640 | 159.0 kb | Distal (>10kb) Multiome | 435 | |
| chr17:8,151,914–8,152,786 | 157.8 kb | Distal (>10kb) Multiome | 633 | |
| chr17:8,153,878–8,154,864 | 155.9 kb | Distal (>10kb) Multiome | 644 | |
| chr17:8,155,928–8,157,418 | 153.7 kb | Distal (>10kb) Multiome | 789 | |
| chr17:8,162,377–8,163,907 | 147.2 kb | Distal (>10kb) Multiome | 637 | |
| chr17:8,172,460–8,174,346 | 136.8 kb | Distal (>10kb) Multiome | 1196 | |
| chr17:8,175,900–8,176,943 | 133.9 kb | Distal (>10kb) Multiome | 601 | |
| chr17:8,185,937–8,188,084 | 122.5 kb | Distal (>10kb) Multiome | 1065 | |
| chr17:8,189,376–8,190,688 | 120.0 kb | Distal (>10kb) Multiome | 748 | |
| chr17:8,192,025–8,192,719 | 117.9 kb | Distal (>10kb) Multiome | 452 | |
| chr17:8,210,139–8,210,786 | 99.7 kb | Distal (>10kb) Multiome | 778 | |
| chr17:8,220,662–8,224,088 | 87.3 kb | Distal (>10kb) Multiome | 1171 | |
| chr17:8,226,529–8,227,280 | 83.5 kb | Distal (>10kb) Multiome | 565 | |
| chr17:8,247,519–8,249,589 | 60.9 kb | Distal (>10kb) Multiome | 914 | |
| chr17:8,288,100–8,289,230 | 21.5 kb | Distal (>10kb) Multiome | 751 | |
| chr17:8,295,073–8,296,021 | 14.8 kb | Distal (>10kb) Multiome | 739 | |
| chr17:8,300,710–8,300,920 | 9.4 kb | Proximal (<10kb) | 319 | |
| chr17:8,310,033–8,310,555 | 15 bp | At TSS Multiome | 98 | |
| chr17:8,313,329–8,313,824 | 3.3 kb | Proximal (<10kb) Multiome | 30 | |
| chr17:8,376,215–8,376,918 | 66.4 kb | Distal (>10kb) Multiome | 888 | |
| chr17:8,382,925–8,384,028 | 73.1 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,435,307–8,436,885 | 125.6 kb | Distal (>10kb) Multiome | 847 | |
| chr17:8,584,054–8,584,700 | 274.1 kb | Distal (>10kb) Multiome | 18 |
Genomic view of the ARHGEF15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.