ARHGAP33

Rho GTPase activating protein 33 | FLJ39019, TCGAP, SNX26

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Biological processes 13 terms

GTPase activator activity (GO:0005096)cytoplasm (GO:0005737)cytosol (GO:0005829)glutamatergic synapse (GO:0098978)phosphatidylinositol binding (GO:0035091)postsynaptic density (GO:0014069)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein-containing complex (GO:0032991)regulation of dendritic spine morphogenesis (GO:0061001)regulation of postsynapse assembly (GO:0150052)signal transduction (GO:0007165)small GTPase-mediated signal transduction (GO:0007264)

Expression (TPM)

TFs regulating ARHGAP33 0 TFs

Transcription factors with Perturb-seq knockdown data for ARHGAP33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARHGAP33

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:35,509,786–35,510,900	265.1 kb	Distal (>10kb) Multiome	650
chr19:35,545,067–35,546,126	229.9 kb	Distal (>10kb) Multiome	879
chr19:35,557,343–35,558,684	217.5 kb	Distal (>10kb) Multiome	452
chr19:35,612,546–35,613,176	162.8 kb	Distal (>10kb) Multiome	778
chr19:35,628,465–35,629,474	146.7 kb	Distal (>10kb) Multiome	889
chr19:35,643,064–35,645,730	132.0 kb	Distal (>10kb) Multiome	1010
chr19:35,648,040–35,648,575	127.3 kb	Distal (>10kb) Multiome	599
chr19:35,673,179–35,673,643	102.1 kb	Distal (>10kb) Multiome	311
chr19:35,702,152–35,702,985	73.1 kb	Distal (>10kb) Multiome	662
chr19:35,716,025–35,718,811	57.8 kb	Distal (>10kb) Multiome	1018
chr19:35,740,083–35,741,430	34.8 kb	Distal (>10kb) Multiome	829
chr19:35,744,481–35,746,086	30.3 kb	Distal (>10kb) Multiome	679
chr19:35,748,170–35,749,017	27.1 kb	Distal (>10kb) Multiome	749
chr19:35,757,432–35,758,657	17.5 kb	Distal (>10kb) Multiome	851
chr19:35,767,601–35,768,256	7.6 kb	Proximal (<10kb) Multiome	276
chr19:35,775,066–35,776,063	57 bp	At TSS Multiome	474
chr19:35,784,357–35,785,306	9.1 kb	Proximal (<10kb) Multiome	183
chr19:35,860,621–35,861,651	85.7 kb	Distal (>10kb) Multiome	299
chr19:35,868,369–35,868,860	92.9 kb	Distal (>10kb) Multiome	320
chr19:35,869,343–35,870,482	94.4 kb	Distal (>10kb) Multiome	492
chr19:35,899,240–35,900,760	124.1 kb	Distal (>10kb) Multiome	751
chr19:35,931,342–35,932,167	156.1 kb	Distal (>10kb) Multiome	835
chr19:35,936,083–35,936,704	160.9 kb	Distal (>10kb) Multiome	417
chr19:35,986,945–35,987,622	211.7 kb	Distal (>10kb) Multiome	363
chr19:35,994,796–35,995,940	219.6 kb	Distal (>10kb) Multiome	897
chr19:36,013,972–36,014,810	238.8 kb	Distal (>10kb) Multiome	623
chr19:36,032,424–36,033,187	257.3 kb	Distal (>10kb) Multiome	179
chr19:36,053,782–36,055,591	278.9 kb	Distal (>10kb) Multiome	1026

Genome Browser

Genomic view of the ARHGAP33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.