ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:24,470,087–24,471,206 | 253.0 kb | Distal (>10kb) Multiome | 271 | |
| chr10:24,551,996–24,552,955 | 171.2 kb | Distal (>10kb) Multiome | 211 | |
| chr10:24,721,336–24,721,971 | 1.3 kb | Proximal (<10kb) | 193 | |
| chr10:24,722,510–24,725,350 | 1.1 kb | Proximal (<10kb) Multiome | 867 | |
| chr10:24,727,604–24,728,280 | 4.4 kb | Proximal (<10kb) | 139 | |
| chr10:24,935,269–24,936,133 | 212.0 kb | Distal (>10kb) Multiome HiCAR | 154 | |
| chr10:24,947,426–24,948,690 | 224.3 kb | Distal (>10kb) Multiome HiCAR | 228 | |
| chr10:24,951,142–24,953,416 | 229.3 kb | Distal (>10kb) Multiome HiCAR | 675 | |
| chr10:25,015,855–25,017,580 | 292.9 kb | Distal (>10kb) Multiome HiCAR | 1101 |
Genomic view of the ARHGAP21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.