This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for ARHGAP12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:31,758,998–31,760,782 | 168.6 kb | Distal (>10kb) Multiome | 813 | |
| chr10:31,927,740–31,929,636 | 86 bp | At TSS Multiome | 953 | |
| chr10:31,929,870–31,930,207 | 1.0 kb | Proximal (<10kb) | 104 | |
| chr10:31,930,317–31,930,602 | 1.5 kb | Proximal (<10kb) | 158 | |
| chr10:32,055,513–32,056,824 | 127.6 kb | Distal (>10kb) Multiome | 887 | |
| chr10:32,150,441–32,151,508 | 222.2 kb | Distal (>10kb) Multiome | 259 |
Genomic view of the ARHGAP12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.