Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in transport vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARFGEF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFGEF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFGEF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:137,866,196–137,868,323 | 294.8 kb | Distal (>10kb) Multiome | 1107 | |
| chr6:138,008,459–138,009,355 | 153.0 kb | Distal (>10kb) Multiome | 116 | |
| chr6:138,086,433–138,087,221 | 75.2 kb | Distal (>10kb) Multiome | 571 | |
| chr6:138,105,499–138,106,672 | 55.7 kb | Distal (>10kb) Multiome | 557 | |
| chr6:138,106,898–138,108,486 | 54.3 kb | Distal (>10kb) Multiome | 878 | |
| chr6:138,160,942–138,162,612 | 49 bp | At TSS Multiome | 699 | |
| chr6:138,240,458–138,241,750 | 79.3 kb | Distal (>10kb) Multiome | 180 | |
| chr6:138,331,206–138,332,418 | 169.8 kb | Distal (>10kb) Multiome | 260 | |
| chr6:138,403,215–138,405,244 | 242.3 kb | Distal (>10kb) Multiome | 1060 |
Genomic view of the ARFGEF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.