The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for ARFGAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFGAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFGAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,006,367–63,007,246 | 265.9 kb | Distal (>10kb) Multiome | 189 | |
| chr20:63,071,594–63,072,696 | 200.9 kb | Distal (>10kb) Multiome | 246 | |
| chr20:63,178,716–63,179,743 | 93.6 kb | Distal (>10kb) Multiome | 386 | |
| chr20:63,215,706–63,216,790 | 56.6 kb | Distal (>10kb) Multiome | 965 | |
| chr20:63,272,274–63,273,137 | 74 bp | At TSS Multiome | 736 | |
| chr20:63,409,631–63,410,124 | 137.1 kb | Distal (>10kb) Multiome | 60 | |
| chr20:63,471,533–63,472,788 | 199.8 kb | Distal (>10kb) Multiome | 219 | |
| chr20:63,488,166–63,488,632 | 215.6 kb | Distal (>10kb) Multiome | 127 | |
| chr20:63,498,850–63,499,391 | 226.4 kb | Distal (>10kb) Multiome | 232 | |
| chr20:63,519,657–63,521,677 | 247.8 kb | Distal (>10kb) Multiome | 712 | |
| chr20:63,537,759–63,538,455 | 265.2 kb | Distal (>10kb) Multiome | 823 | |
| chr20:63,552,551–63,554,733 | 280.7 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the ARFGAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.