This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARCN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARCN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARCN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,152,392–118,153,276 | 419.5 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr11:118,359,034–118,359,890 | 212.9 kb | Distal (>10kb) Multiome | 779 | |
| chr11:118,401,086–118,402,051 | 170.9 kb | Distal (>10kb) Multiome | 732 | |
| chr11:118,434,505–118,437,761 | 136.1 kb | Distal (>10kb) Multiome | 1053 | |
| chr11:118,530,432–118,531,848 | 41.3 kb | Distal (>10kb) Multiome | 763 | |
| chr11:118,565,807–118,566,209 | 6.2 kb | Proximal (<10kb) | 563 | |
| chr11:118,571,906–118,572,919 | 23 bp | At TSS Multiome | 760 | |
| chr11:118,610,391–118,611,672 | 38.8 kb | Distal (>10kb) Multiome | 488 | |
| chr11:118,620,694–118,621,880 | 49.0 kb | Distal (>10kb) Multiome | 683 | |
| chr11:118,634,418–118,635,567 | 62.6 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 87.2 kb | Distal (>10kb) Multiome | 459 | |
| chr11:118,689,268–118,690,813 | 117.7 kb | Distal (>10kb) Multiome | 804 | |
| chr11:118,714,768–118,715,435 | 142.4 kb | Distal (>10kb) Multiome | 87 | |
| chr11:118,715,577–118,717,605 | 144.8 kb | Distal (>10kb) Multiome | 445 | |
| chr11:118,789,603–118,790,362 | 217.4 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 220.5 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the ARCN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.