Transcription factors with Perturb-seq knockdown data for APTR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APTR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APTR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:77,415,516–77,416,893 | 279.8 kb | Distal (>10kb) Multiome | 711 | |
| chr7:77,536,195–77,538,947 | 159.3 kb | Distal (>10kb) Multiome | 1033 | |
| chr7:77,695,815–77,697,645 | 73 bp | At TSS Multiome | 929 | |
| chr7:77,797,902–77,799,769 | 102.4 kb | Distal (>10kb) Multiome | 1053 |
Genomic view of the APTR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.