This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for APOOL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOOL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOOL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:84,729,775–84,730,561 | 273.8 kb | Distal (>10kb) Multiome | 201 | |
| chrX:84,744,008–84,745,142 | 259.1 kb | Distal (>10kb) Multiome | 54 | |
| chrX:85,002,863–85,003,519 | 356 bp | At TSS | 77 | |
| chrX:85,003,643–85,004,275 | 76 bp | At TSS Multiome | 512 | |
| chrX:85,243,518–85,245,241 | 240.1 kb | Distal (>10kb) Multiome | 437 |
Genomic view of the APOOL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.