APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]
Transcription factors with Perturb-seq knockdown data for APOLD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOLD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOLD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,561,525–12,563,261 | 163.1 kb | Distal (>10kb) Multiome | 768 | |
| chr12:12,611,502–12,612,657 | 114.1 kb | Distal (>10kb) Multiome | 980 | |
| chr12:12,684,299–12,685,064 | 41.2 kb | Distal (>10kb) Multiome | 306 | |
| chr12:12,693,129–12,694,039 | 32.3 kb | Distal (>10kb) Multiome | 190 | |
| chr12:12,695,955–12,697,008 | 29.5 kb | Distal (>10kb) Multiome | 568 | |
| chr12:12,716,729–12,717,910 | 8.7 kb | Proximal (<10kb) Multiome | 799 | |
| chr12:12,723,708–12,726,164 | 305 bp | At TSS Multiome | 958 | |
| chr12:12,742,773–12,743,975 | 17.3 kb | Distal (>10kb) Multiome | 118 | |
| chr12:12,775,741–12,776,742 | 50.5 kb | Distal (>10kb) Multiome | 267 | |
| chr12:12,786,507–12,787,490 | 61.0 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,799,298–12,799,907 | 73.7 kb | Distal (>10kb) Multiome | 137 | |
| chr12:12,812,936–12,813,661 | 87.4 kb | Distal (>10kb) Multiome | 700 | |
| chr12:12,890,573–12,891,789 | 165.0 kb | Distal (>10kb) Multiome | 656 | |
| chr12:12,999,403–13,001,860 | 274.4 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the APOLD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.