This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Transcription factors with Perturb-seq knockdown data for APOL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:35,627,232–35,627,966 | 533.2 kb | Distal (>10kb) Multiome HiCAR | 482 | |
| chr22:36,027,992–36,029,495 | 131.8 kb | Distal (>10kb) Multiome | 652 | |
| chr22:36,065,574–36,066,549 | 94.8 kb | Distal (>10kb) Multiome | 778 | |
| chr22:36,123,849–36,124,433 | 36.6 kb | Distal (>10kb) Multiome | 670 | |
| chr22:36,161,582–36,162,255 | 1.2 kb | Proximal (<10kb) Multiome | 66 | |
| chr22:36,172,028–36,172,599 | 11.5 kb | Distal (>10kb) Multiome | 53 | |
| chr22:36,386,961–36,388,711 | 227.4 kb | Distal (>10kb) Multiome | 830 | |
| chr22:36,409,675–36,410,687 | 249.5 kb | Distal (>10kb) Multiome | 707 | |
| chr22:36,454,782–36,455,724 | 294.5 kb | Distal (>10kb) Multiome | 598 | |
| chr22:36,459,142–36,459,906 | 298.8 kb | Distal (>10kb) Multiome | 269 |
Genomic view of the APOL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.