The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for APOE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,643,571–44,644,620 | 261.9 kb | Distal (>10kb) Multiome | 710 | |
| chr19:44,747,085–44,747,789 | 158.2 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 148.4 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 146.9 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 135.0 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 127.9 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 105.2 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 97.7 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 61.0 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 14.9 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 2.0 kb | Proximal (<10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 899 bp | At TSS Multiome | 645 | |
| chr19:44,909,850–44,910,571 | 4.1 kb | Proximal (<10kb) | 146 | |
| chr19:44,911,026–44,911,489 | 5.2 kb | Proximal (<10kb) | 533 | |
| chr19:44,913,546–44,915,671 | 9.4 kb | Proximal (<10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 21.4 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 49.5 kb | Distal (>10kb) Multiome HiCAR | 835 | |
| chr19:45,001,031–45,002,639 | 95.6 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 133.3 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 170.7 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 174.4 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 187.2 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 272.7 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the APOE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.