This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for APLP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APLP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APLP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:129,815,544–129,816,526 | 254.0 kb | Distal (>10kb) Multiome | 315 | |
| chr11:129,894,845–129,896,318 | 174.3 kb | Distal (>10kb) Multiome | 678 | |
| chr11:130,001,573–130,003,849 | 67.1 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:130,068,597–130,071,216 | 180 bp | At TSS Multiome | 898 | |
| chr11:130,076,579–130,077,560 | 7.1 kb | Proximal (<10kb) Multiome | 129 | |
| chr11:130,146,013–130,146,727 | 76.6 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 90.0 kb | Distal (>10kb) Multiome | 309 | |
| chr11:130,212,937–130,213,600 | 143.4 kb | Distal (>10kb) Multiome | 321 | |
| chr11:130,314,035–130,315,987 | 244.9 kb | Distal (>10kb) Multiome | 766 | |
| chr11:131,904,647–131,905,209 | 1835.1 kb | Distal (>10kb) Multiome HiCAR | 128 |
Genomic view of the APLP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.