The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for APBB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APBB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APBB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:140,302,631–140,303,538 | 261.6 kb | Distal (>10kb) Multiome | 552 | |
| chr5:140,345,869–140,347,147 | 218.0 kb | Distal (>10kb) Multiome | 671 | |
| chr5:140,363,055–140,363,697 | 201.3 kb | Distal (>10kb) Multiome | 542 | |
| chr5:140,372,779–140,373,538 | 191.5 kb | Distal (>10kb) Multiome | 302 | |
| chr5:140,400,395–140,402,925 | 163.1 kb | Distal (>10kb) Multiome | 1129 | |
| chr5:140,546,917–140,548,500 | 17.0 kb | Distal (>10kb) Multiome | 784 | |
| chr5:140,556,971–140,557,959 | 7.2 kb | Proximal (<10kb) Multiome | 886 | |
| chr5:140,564,055–140,565,123 | 68 bp | At TSS Multiome | 827 | |
| chr5:140,574,195–140,574,528 | 9.5 kb | Proximal (<10kb) | 115 | |
| chr5:140,639,043–140,640,146 | 74.7 kb | Distal (>10kb) Multiome HiCAR | 898 | |
| chr5:140,647,175–140,648,159 | 83.0 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr5:140,664,368–140,665,161 | 100.1 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,691,053–140,691,933 | 126.8 kb | Distal (>10kb) Multiome | 924 | |
| chr5:140,699,981–140,700,742 | 135.7 kb | Distal (>10kb) Multiome | 607 | |
| chr5:140,710,433–140,711,671 | 146.4 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr5:140,718,340–140,718,978 | 153.9 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chr5:140,725,570–140,726,438 | 161.3 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the APBB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.