The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for APBA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APBA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APBA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:28,832,103–28,832,591 | 53.9 kb | Distal (>10kb) Multiome | 201 | |
| chr15:28,885,430–28,886,683 | 146 bp | At TSS Multiome | 340 | |
| chr15:28,918,134–28,918,812 | 32.3 kb | Distal (>10kb) Multiome | 129 | |
| chr15:29,103,497–29,104,203 | 217.8 kb | Distal (>10kb) Multiome | 244 | |
| chr15:29,129,572–29,130,462 | 243.9 kb | Distal (>10kb) Multiome | 57 | |
| chr15:29,139,629–29,141,091 | 253.9 kb | Distal (>10kb) Multiome | 391 | |
| chr15:29,162,166–29,163,015 | 276.5 kb | Distal (>10kb) Multiome | 45 |
Genomic view of the APBA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.