Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of AP-3 adaptor complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for AP3S2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP3S2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP3S2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,647,189–89,647,621 | 246.7 kb | Distal (>10kb) Multiome | 323 | |
| chr15:89,654,859–89,655,986 | 238.5 kb | Distal (>10kb) Multiome | 484 | |
| chr15:89,665,508–89,666,065 | 228.2 kb | Distal (>10kb) Multiome | 279 | |
| chr15:89,690,263–89,691,125 | 203.3 kb | Distal (>10kb) Multiome | 669 | |
| chr15:89,747,326–89,748,774 | 146.0 kb | Distal (>10kb) Multiome HiCAR | 214 | |
| chr15:89,750,169–89,751,978 | 143.1 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr15:89,760,201–89,761,182 | 133.3 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr15:89,775,879–89,777,425 | 117.4 kb | Distal (>10kb) Multiome | 647 | |
| chr15:89,893,669–89,894,442 | 75 bp | At TSS Multiome | 1083 | |
| chr15:89,898,712–89,898,956 | 4.7 kb | Proximal (<10kb) | 190 | |
| chr15:89,912,261–89,913,121 | 18.8 kb | Distal (>10kb) Multiome | 514 | |
| chr15:89,999,673–90,000,089 | 105.9 kb | Distal (>10kb) Multiome | 174 | |
| chr15:90,001,237–90,002,666 | 107.8 kb | Distal (>10kb) Multiome | 589 | |
| chr15:90,059,488–90,060,208 | 165.8 kb | Distal (>10kb) Multiome HiCAR | 439 | |
| chr15:90,061,829–90,062,285 | 168.1 kb | Distal (>10kb) Multiome | 347 | |
| chr15:90,075,459–90,076,479 | 182.0 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr15:90,101,730–90,103,001 | 208.5 kb | Distal (>10kb) Multiome | 693 | |
| chr15:90,143,210–90,143,683 | 249.4 kb | Distal (>10kb) Multiome | 578 | |
| chr15:90,152,072–90,152,533 | 258.3 kb | Distal (>10kb) Multiome | 92 | |
| chr15:90,157,949–90,158,473 | 264.2 kb | Distal (>10kb) Multiome | 670 | |
| chr15:90,184,585–90,185,456 | 291.0 kb | Distal (>10kb) Multiome | 806 |
Genomic view of the AP3S2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.