Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AP1G1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1G1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1G1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,526,040–71,526,860 | 282.4 kb | Distal (>10kb) Multiome | 294 | |
| chr16:71,564,628–71,565,649 | 243.8 kb | Distal (>10kb) Multiome | 792 | |
| chr16:71,625,835–71,627,289 | 182.7 kb | Distal (>10kb) Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 85.7 kb | Distal (>10kb) Multiome | 894 | |
| chr16:71,808,251–71,809,603 | 314 bp | At TSS Multiome | 1032 | |
| chr16:71,845,428–71,846,392 | 37.1 kb | Distal (>10kb) Multiome | 923 | |
| chr16:71,883,009–71,884,742 | 75.3 kb | Distal (>10kb) Multiome | 791 | |
| chr16:71,894,288–71,896,022 | 86.6 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:71,981,752–71,982,390 | 173.2 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,008,426–72,009,172 | 199.8 kb | Distal (>10kb) Multiome | 815 | |
| chr16:72,013,585–72,014,228 | 205.2 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,093,288–72,094,355 | 284.9 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the AP1G1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.