Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for AP1B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,205,602–29,206,473 | 182.5 kb | Distal (>10kb) Multiome | 378 | |
| chr22:29,267,574–29,268,917 | 120.4 kb | Distal (>10kb) Multiome | 969 | |
| chr22:29,304,664–29,307,808 | 81.6 kb | Distal (>10kb) Multiome | 839 | |
| chr22:29,313,065–29,313,784 | 75.2 kb | Distal (>10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 72.9 kb | Distal (>10kb) Multiome | 242 | |
| chr22:29,388,161–29,388,971 | 82 bp | At TSS Multiome | 740 | |
| chr22:29,395,049–29,395,255 | 6.5 kb | Proximal (<10kb) | 285 | |
| chr22:29,431,916–29,432,715 | 43.8 kb | Distal (>10kb) Multiome | 14 | |
| chr22:29,470,132–29,470,844 | 81.9 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 92.5 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 165.2 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 192.6 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 215.0 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the AP1B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.