This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for AOPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AOPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AOPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:94,552,994–94,555,388 | 171.9 kb | Distal (>10kb) Multiome | 631 | |
| chr9:94,608,138–94,608,779 | 118.3 kb | Distal (>10kb) Multiome | 331 | |
| chr9:94,639,019–94,639,691 | 87.3 kb | Distal (>10kb) Multiome | 277 | |
| chr9:94,639,882–94,640,360 | 86.5 kb | Distal (>10kb) Multiome | 156 | |
| chr9:94,696,327–94,696,930 | 30.0 kb | Distal (>10kb) Multiome | 18 | |
| chr9:94,717,714–94,718,021 | 8.7 kb | Proximal (<10kb) | 38 | |
| chr9:94,726,305–94,727,294 | 24 bp | At TSS Multiome | 856 | |
| chr9:94,746,310–94,746,827 | 19.9 kb | Distal (>10kb) Multiome | 82 | |
| chr9:95,004,358–95,005,432 | 278.2 kb | Distal (>10kb) Multiome | 598 | |
| chr9:95,031,801–95,032,726 | 305.6 kb | Distal (>10kb) Multiome HiCAR | 396 |
Genomic view of the AOPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.