Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for ANXA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANXA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANXA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:69,450,768–69,451,516 | 290.8 kb | Distal (>10kb) Multiome | 69 | |
| chr2:69,642,875–69,644,362 | 98.1 kb | Distal (>10kb) Multiome | 960 | |
| chr2:69,741,315–69,742,479 | 11 bp | At TSS Multiome | 894 | |
| chr2:69,798,793–69,799,774 | 57.3 kb | Distal (>10kb) Multiome | 417 | |
| chr2:69,829,001–69,830,537 | 87.6 kb | Distal (>10kb) Multiome HiCAR | 1005 | |
| chr2:69,914,102–69,915,874 | 172.8 kb | Distal (>10kb) Multiome | 1112 |
Genomic view of the ANXA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.