This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for ANXA11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANXA11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANXA11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:79,444,238–79,447,010 | 759.7 kb | Distal (>10kb) Multiome HiCAR | 851 | |
| chr10:79,981,449–79,982,593 | 223.5 kb | Distal (>10kb) Multiome | 420 | |
| chr10:80,076,334–80,077,082 | 129.0 kb | Distal (>10kb) Multiome | 10 | |
| chr10:80,078,334–80,079,521 | 126.6 kb | Distal (>10kb) Multiome | 806 | |
| chr10:80,132,279–80,133,011 | 72.9 kb | Distal (>10kb) Multiome | 155 | |
| chr10:80,203,507–80,203,886 | 1.6 kb | Proximal (<10kb) | 477 | |
| chr10:80,204,160–80,204,638 | 898 bp | At TSS | 198 | |
| chr10:80,204,736–80,206,157 | 38 bp | At TSS Multiome | 830 | |
| chr10:80,207,076–80,207,999 | 2.0 kb | Proximal (<10kb) Multiome | 466 | |
| chr10:80,265,707–80,266,498 | 60.5 kb | Distal (>10kb) Multiome | 166 | |
| chr10:80,356,265–80,357,947 | 151.4 kb | Distal (>10kb) Multiome | 316 | |
| chr10:80,407,698–80,409,441 | 203.0 kb | Distal (>10kb) Multiome | 766 | |
| chr10:80,453,293–80,455,470 | 248.6 kb | Distal (>10kb) Multiome | 715 | |
| chr10:80,460,762–80,461,239 | 255.4 kb | Distal (>10kb) Multiome | 249 | |
| chr10:80,464,428–80,465,474 | 259.3 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the ANXA11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.