Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including negative regulation of apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANP32B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANP32B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANP32B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,696,750–97,697,733 | 286.0 kb | Distal (>10kb) Multiome | 836 | |
| chr9:97,710,703–97,711,693 | 272.1 kb | Distal (>10kb) Multiome | 257 | |
| chr9:97,741,053–97,741,796 | 241.9 kb | Distal (>10kb) Multiome | 305 | |
| chr9:97,803,235–97,804,055 | 179.7 kb | Distal (>10kb) Multiome | 679 | |
| chr9:97,853,103–97,855,002 | 129.3 kb | Distal (>10kb) Multiome | 323 | |
| chr9:97,922,022–97,923,085 | 60.9 kb | Distal (>10kb) Multiome | 1110 | |
| chr9:97,982,380–97,985,451 | 1.4 kb | Proximal (<10kb) Multiome | 994 | |
| chr9:98,056,283–98,057,271 | 73.3 kb | Distal (>10kb) Multiome | 868 | |
| chr9:98,087,291–98,088,183 | 104.4 kb | Distal (>10kb) Multiome | 281 | |
| chr9:98,118,693–98,119,508 | 135.8 kb | Distal (>10kb) Multiome | 752 | |
| chr9:98,191,695–98,193,531 | 209.7 kb | Distal (>10kb) Multiome | 795 | |
| chr9:98,218,786–98,219,246 | 235.7 kb | Distal (>10kb) Multiome | 178 | |
| chr9:98,255,174–98,256,530 | 272.5 kb | Distal (>10kb) Multiome | 905 | |
| chr9:98,265,141–98,265,693 | 282.2 kb | Distal (>10kb) Multiome | 26 | |
| chr9:98,280,310–98,281,125 | 297.4 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the ANP32B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.