Enables ubiquitin-like ligase-substrate adaptor activity. Involved in intracellular copper ion homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytoplasmic vesicle and cytosol. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKRD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:102,247,845–102,248,746 | 261.4 kb | Distal (>10kb) Multiome | 142 | |
| chr14:102,304,511–102,305,687 | 204.6 kb | Distal (>10kb) Multiome | 568 | |
| chr14:102,314,028–102,314,685 | 195.4 kb | Distal (>10kb) Multiome | 720 | |
| chr14:102,316,590–102,317,741 | 192.7 kb | Distal (>10kb) Multiome | 885 | |
| chr14:102,319,368–102,320,458 | 190.1 kb | Distal (>10kb) Multiome | 675 | |
| chr14:102,362,620–102,363,583 | 146.8 kb | Distal (>10kb) Multiome | 705 | |
| chr14:102,507,117–102,508,097 | 2.2 kb | Proximal (<10kb) Multiome | 100 | |
| chr14:102,508,416–102,511,398 | 98 bp | At TSS Multiome | 778 | |
| chr14:102,516,500–102,517,914 | 7.2 kb | Proximal (<10kb) Multiome | 694 | |
| chr14:102,524,045–102,525,126 | 15.0 kb | Distal (>10kb) Multiome | 817 | |
| chr14:102,545,130–102,546,123 | 35.9 kb | Distal (>10kb) Multiome | 458 | |
| chr14:102,554,738–102,555,873 | 45.8 kb | Distal (>10kb) Multiome | 280 | |
| chr14:102,585,306–102,585,775 | 75.8 kb | Distal (>10kb) Multiome | 259 | |
| chr14:102,591,431–102,593,846 | 82.7 kb | Distal (>10kb) Multiome | 895 | |
| chr14:102,776,966–102,778,132 | 267.6 kb | Distal (>10kb) Multiome | 446 | |
| chr14:102,927,667–102,929,100 | 418.8 kb | Distal (>10kb) Multiome HiCAR | 328 | |
| chr14:102,929,570–102,930,980 | 420.6 kb | Distal (>10kb) Multiome HiCAR | 178 |
Genomic view of the ANKRD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.