This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for ANKRD46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:100,145,361–100,146,165 | 413.9 kb | Distal (>10kb) Multiome HiCAR | 584 | |
| chr8:100,149,973–100,150,933 | 409.2 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr8:100,157,695–100,158,647 | 401.6 kb | Distal (>10kb) Multiome HiCAR | 728 | |
| chr8:100,212,742–100,213,750 | 346.7 kb | Distal (>10kb) Multiome HiCAR | 792 | |
| chr8:100,309,111–100,310,745 | 249.6 kb | Distal (>10kb) Multiome | 964 | |
| chr8:100,335,686–100,336,642 | 223.5 kb | Distal (>10kb) Multiome | 284 | |
| chr8:100,375,327–100,376,046 | 184.0 kb | Distal (>10kb) Multiome | 241 | |
| chr8:100,559,150–100,560,136 | 33 bp | At TSS Multiome | 918 | |
| chr8:100,564,060–100,564,302 | 4.3 kb | Proximal (<10kb) | 268 | |
| chr8:100,648,945–100,649,791 | 89.7 kb | Distal (>10kb) Multiome | 186 | |
| chr8:100,720,634–100,723,228 | 162.6 kb | Distal (>10kb) Multiome | 1037 | |
| chr8:100,809,500–100,810,195 | 250.1 kb | Distal (>10kb) Multiome | 204 | |
| chr8:100,847,178–100,847,780 | 287.8 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the ANKRD46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.