Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKIB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKIB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKIB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,133,257–92,135,349 | 112.2 kb | Distal (>10kb) Multiome | 1155 | |
| chr7:92,178,862–92,179,934 | 66.9 kb | Distal (>10kb) Multiome | 612 | |
| chr7:92,245,288–92,246,980 | 114 bp | At TSS Multiome | 964 | |
| chr7:92,424,381–92,424,856 | 178.7 kb | Distal (>10kb) Multiome | 634 | |
| chr7:92,447,026–92,448,601 | 201.5 kb | Distal (>10kb) Multiome | 973 | |
| chr7:92,483,511–92,484,016 | 237.8 kb | Distal (>10kb) Multiome | 84 | |
| chr7:92,527,585–92,529,221 | 282.6 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the ANKIB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.