Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKDD1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKDD1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKDD1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:75,336,144–75,337,997 | 274.4 kb | Distal (>10kb) Multiome | 912 | |
| chr5:75,510,698–75,512,248 | 99.7 kb | Distal (>10kb) Multiome | 941 | |
| chr5:75,606,780–75,607,252 | 4.2 kb | Proximal (<10kb) | 44 | |
| chr5:75,610,714–75,612,105 | 238 bp | At TSS Multiome | 445 | |
| chr5:75,612,238–75,612,536 | 786 bp | At TSS | 61 | |
| chr5:75,716,816–75,717,900 | 106.0 kb | Distal (>10kb) Multiome | 836 |
Genomic view of the ANKDD1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.