This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for ANGPTL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGPTL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGPTL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,148,316–8,149,986 | 214.9 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 160.5 kb | Distal (>10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 155.2 kb | Distal (>10kb) Multiome | 712 | |
| chr19:8,268,737–8,269,370 | 95.4 kb | Distal (>10kb) Multiome | 272 | |
| chr19:8,307,739–8,308,717 | 56.1 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,314,738–8,315,490 | 49.4 kb | Distal (>10kb) Multiome | 49 | |
| chr19:8,320,824–8,321,811 | 43.0 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 29.1 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 21.1 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,354,026–8,354,228 | 9.9 kb | Proximal (<10kb) | 391 | |
| chr19:8,363,586–8,364,765 | 314 bp | At TSS Multiome | 549 | |
| chr19:8,367,410–8,367,772 | 3.3 kb | Proximal (<10kb) | 364 | |
| chr19:8,389,684–8,391,548 | 25.8 kb | Distal (>10kb) Multiome | 878 | |
| chr19:8,412,769–8,413,775 | 48.8 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 80.5 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 141.9 kb | Distal (>10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 147.6 kb | Distal (>10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 149.6 kb | Distal (>10kb) Multiome | 825 | |
| chr19:8,525,196–8,527,085 | 161.4 kb | Distal (>10kb) Multiome | 783 | |
| chr19:8,580,484–8,581,056 | 216.5 kb | Distal (>10kb) Multiome | 535 | |
| chr19:8,591,781–8,593,224 | 228.1 kb | Distal (>10kb) Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 245.1 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,610,265–8,610,915 | 246.5 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the ANGPTL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.