This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for ANAPC13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:134,250,095–134,251,199 | 235.2 kb | Distal (>10kb) Multiome | 719 | |
| chr3:134,308,427–134,308,921 | 177.3 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr3:134,312,827–134,313,997 | 172.5 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr3:134,333,562–134,334,597 | 152.1 kb | Distal (>10kb) Multiome | 224 | |
| chr3:134,363,600–134,365,141 | 121.7 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr3:134,372,925–134,375,830 | 111.3 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr3:134,406,305–134,407,815 | 79.1 kb | Distal (>10kb) Multiome | 295 | |
| chr3:134,485,113–134,486,743 | 63 bp | At TSS Multiome | 1009 | |
| chr3:134,600,919–134,601,384 | 115.1 kb | Distal (>10kb) Multiome | 224 | |
| chr3:134,640,811–134,642,504 | 155.9 kb | Distal (>10kb) Multiome | 257 | |
| chr3:134,650,423–134,651,401 | 165.0 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the ANAPC13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.