ANAPC11
anaphase promoting complex subunit 11 | APC11, Apc11p, HSPC214, MGC882

Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1
Biological processes 39 terms
G protein-coupled receptor binding (GO:0001664)anaphase-promoting complex (GO:0005680)anaphase-promoting complex (GO:0005680)anaphase-promoting complex (GO:0005680)anaphase-promoting complex-dependent catabolic process (GO:0031145)anaphase-promoting complex-dependent catabolic process (GO:0031145)anaphase-promoting complex-dependent catabolic process (GO:0031145)cullin family protein binding (GO:0097602)cullin family protein binding (GO:0097602)cullin family protein binding (GO:0097602)cullin-RING ubiquitin ligase complex (GO:0031461)cytoplasm (GO:0005737)cytosol (GO:0005829)mitotic cell cycle (GO:0000278)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of mitotic metaphase/anaphase transition (GO:0045842)positive regulation of mitotic metaphase/anaphase transition (GO:0045842)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K11-linked ubiquitination (GO:0070979)protein K48-linked ubiquitination (GO:0070936)protein binding (GO:0005515)protein branched polyubiquitination (GO:0141198)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of meiotic cell cycle (GO:0051445)regulation of mitotic cell cycle (GO:0007346)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-ubiquitin ligase activity (GO:0034450)zinc ion binding (GO:0008270)
Expression (TPM)
ANAPC11 — as a Regulated Gene

TFs regulating ANAPC11 0 TFs

Transcription factors with Perturb-seq knockdown data for ANAPC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ANAPC11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:81,636,404–81,637,301 254.7 kb Distal (>10kb) Multiome 946
chr17:81,648,048–81,648,550 243.5 kb Distal (>10kb) Multiome 88
chr17:81,652,970–81,653,572 238.6 kb Distal (>10kb) Multiome 188
chr17:81,666,251–81,667,166 225.1 kb Distal (>10kb) Multiome 901
chr17:81,683,344–81,684,556 207.8 kb Distal (>10kb) Multiome 926
chr17:81,702,879–81,703,868 188.3 kb Distal (>10kb) Multiome 981
chr17:81,711,721–81,712,812 179.5 kb Distal (>10kb) Multiome 1056
chr17:81,832,473–81,833,976 58.5 kb Distal (>10kb) Multiome 1015
chr17:81,859,762–81,861,595 30.9 kb Distal (>10kb) Multiome 1134
chr17:81,868,421–81,868,978 23.2 kb Distal (>10kb) Multiome 577
chr17:81,869,000–81,872,289 20.5 kb Distal (>10kb) Multiome 1136
chr17:81,891,143–81,892,257 46 bp At TSS Multiome 969
chr17:81,910,443–81,911,980 19.8 kb Distal (>10kb) Multiome 806
chr17:81,917,586–81,918,522 26.4 kb Distal (>10kb) Multiome 619
chr17:81,923,285–81,923,863 31.8 kb Distal (>10kb) Multiome 399
chr17:81,926,141–81,929,133 36.2 kb Distal (>10kb) Multiome 1034
chr17:81,936,855–81,937,682 45.6 kb Distal (>10kb) Multiome 854
chr17:81,959,299–81,962,169 68.0 kb Distal (>10kb) Multiome 805
chr17:81,966,804–81,968,359 76.3 kb Distal (>10kb) Multiome 908
chr17:81,976,595–81,978,312 85.9 kb Distal (>10kb) Multiome 1001
chr17:82,019,856–82,020,391 128.4 kb Distal (>10kb) Multiome 436
chr17:82,022,355–82,024,111 131.4 kb Distal (>10kb) Multiome 898
chr17:82,029,976–82,032,662 140.2 kb Distal (>10kb) Multiome 695
chr17:82,036,902–82,037,961 145.9 kb Distal (>10kb) Multiome 892
chr17:82,051,387–82,052,184 160.1 kb Distal (>10kb) Multiome 479
chr17:82,065,558–82,066,150 174.1 kb Distal (>10kb) Multiome 967
chr17:82,096,478–82,100,203 206.8 kb Distal (>10kb) Multiome 1085
chr17:82,103,334–82,104,356 211.9 kb Distal (>10kb) Multiome 672

Genome Browser

Genomic view of the ANAPC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:81,626,404 – 82,114,356
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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