This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ANAPC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:111,883,652–111,884,536 | 11 bp | At TSS Multiome | 911 | |
| chr2:111,897,537–111,899,424 | 14.2 kb | Distal (>10kb) Multiome | 926 | |
| chr2:112,047,188–112,048,562 | 163.7 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr2:112,053,884–112,054,856 | 170.6 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr2:112,054,956–112,056,432 | 171.0 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr2:112,181,502–112,182,275 | 297.7 kb | Distal (>10kb) Multiome | 174 | |
| chr2:112,583,940–112,585,172 | 700.4 kb | Distal (>10kb) Multiome HiCAR | 949 |
Genomic view of the ANAPC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.