Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for AMOTL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMOTL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMOTL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:134,250,095–134,251,199 | 123.0 kb | Distal (>10kb) Multiome | 719 | |
| chr3:134,308,427–134,308,921 | 65.1 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr3:134,312,827–134,313,997 | 60.3 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr3:134,333,562–134,334,597 | 39.9 kb | Distal (>10kb) Multiome HiCAR | 224 | |
| chr3:134,363,600–134,365,141 | 9.5 kb | Proximal (<10kb) Multiome | 492 | |
| chr3:134,370,447–134,371,244 | 667 bp | At TSS | 111 | |
| chr3:134,371,349–134,372,310 | at TSS | At TSS | 112 | |
| chr3:134,372,925–134,375,830 | 847 bp | At TSS Multiome | 1010 | |
| chr3:134,378,436–134,378,673 | 6.5 kb | Proximal (<10kb) | 175 | |
| chr3:134,406,305–134,407,815 | 33.1 kb | Distal (>10kb) Multiome | 295 | |
| chr3:134,485,113–134,486,743 | 112.3 kb | Distal (>10kb) Multiome HiCAR | 1009 | |
| chr3:134,600,919–134,601,384 | 227.3 kb | Distal (>10kb) Multiome | 224 | |
| chr3:134,640,811–134,642,504 | 268.1 kb | Distal (>10kb) Multiome | 257 | |
| chr3:134,650,423–134,651,401 | 277.2 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the AMOTL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.