The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for AMOTL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMOTL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMOTL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,493,226–94,494,559 | 274.4 kb | Distal (>10kb) Multiome | 772 | |
| chr11:94,512,016–94,512,839 | 255.9 kb | Distal (>10kb) Multiome | 343 | |
| chr11:94,543,659–94,545,776 | 224.1 kb | Distal (>10kb) Multiome | 824 | |
| chr11:94,643,177–94,643,647 | 124.9 kb | Distal (>10kb) Multiome HiCAR | 75 | |
| chr11:94,649,720–94,650,679 | 118.1 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr11:94,734,354–94,735,444 | 33.7 kb | Distal (>10kb) Multiome | 313 | |
| chr11:94,740,333–94,741,667 | 27.6 kb | Distal (>10kb) Multiome | 433 | |
| chr11:94,765,571–94,766,489 | 1.9 kb | Proximal (<10kb) | 14 | |
| chr11:94,766,900–94,769,104 | 1.2 kb | Proximal (<10kb) Multiome | 701 | |
| chr11:94,770,809–94,770,930 | 2.5 kb | Proximal (<10kb) | 25 | |
| chr11:94,776,152–94,777,329 | 7.8 kb | Proximal (<10kb) | 308 | |
| chr11:94,866,030–94,867,452 | 98.3 kb | Distal (>10kb) Multiome | 112 | |
| chr11:94,973,096–94,974,006 | 205.3 kb | Distal (>10kb) Multiome | 740 | |
| chr11:95,066,821–95,068,191 | 299.0 kb | Distal (>10kb) Multiome | 721 |
Genomic view of the AMOTL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.