Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AMN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,589,796–31,591,586 | 138.0 kb | Distal (>10kb) Multiome | 875 | |
| chr12:31,659,057–31,659,786 | 69.8 kb | Distal (>10kb) Multiome | 737 | |
| chr12:31,723,549–31,723,765 | 5.3 kb | Proximal (<10kb) | 113 | |
| chr12:31,728,407–31,729,774 | 20 bp | At TSS Multiome | 938 | |
| chr12:31,732,968–31,733,511 | 4.2 kb | Proximal (<10kb) Multiome | 430 | |
| chr12:31,749,119–31,749,785 | 20.3 kb | Distal (>10kb) Multiome | 885 | |
| chr12:31,896,572–31,897,018 | 167.7 kb | Distal (>10kb) Multiome | 385 | |
| chr12:31,958,831–31,959,907 | 230.3 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr12:31,966,416–31,967,293 | 237.7 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr12:32,016,824–32,017,328 | 288.0 kb | Distal (>10kb) Multiome | 159 | |
| chr12:32,022,349–32,022,802 | 293.5 kb | Distal (>10kb) Multiome | 56 | |
| chr12:32,398,922–32,400,774 | 670.5 kb | Distal (>10kb) Multiome HiCAR | 832 |
Genomic view of the AMN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.