Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AMMECR1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMMECR1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMMECR1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,591,279–127,591,967 | 294.4 kb | Distal (>10kb) Multiome | 431 | |
| chr2:127,674,653–127,675,849 | 210.7 kb | Distal (>10kb) Multiome | 324 | |
| chr2:127,700,417–127,702,395 | 184.4 kb | Distal (>10kb) Multiome | 1115 | |
| chr2:127,810,532–127,811,650 | 74.8 kb | Distal (>10kb) Multiome | 948 | |
| chr2:127,857,714–127,858,658 | 27.8 kb | Distal (>10kb) Multiome | 924 | |
| chr2:127,859,716–127,860,274 | 26.1 kb | Distal (>10kb) Multiome | 286 | |
| chr2:127,884,757–127,885,049 | 917 bp | At TSS | 173 | |
| chr2:127,885,860–127,886,795 | 328 bp | At TSS Multiome | 331 | |
| chr2:128,026,821–128,028,727 | 141.4 kb | Distal (>10kb) Multiome | 872 | |
| chr2:128,090,830–128,091,736 | 205.2 kb | Distal (>10kb) Multiome | 987 |
Genomic view of the AMMECR1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.