Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be active in membrane. Biomarker of gastric adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AMIGO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMIGO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMIGO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:47,071,164–47,071,564 | 8.3 kb | Proximal (<10kb) | 75 | |
| chr12:47,079,343–47,080,725 | 37 bp | At TSS Multiome | 614 | |
| chr12:47,080,827–47,081,048 | 962 bp | At TSS | 342 | |
| chr12:47,083,245–47,083,522 | 3.4 kb | Proximal (<10kb) | 181 | |
| chr12:47,085,281–47,085,406 | 5.4 kb | Proximal (<10kb) | 115 | |
| chr12:47,085,859–47,086,274 | 6.0 kb | Proximal (<10kb) | 344 | |
| chr12:47,206,926–47,207,587 | 127.2 kb | Distal (>10kb) Multiome | 292 | |
| chr12:47,249,264–47,250,499 | 170.0 kb | Distal (>10kb) Multiome | 235 | |
| chr12:47,286,476–47,287,027 | 206.9 kb | Distal (>10kb) Multiome | 67 |
Genomic view of the AMIGO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.