AMDHD2
amidohydrolase domain containing 2 | CGI-14

Enables N-acetylglucosamine-6-phosphate deacetylase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-9 DE-9.4
Biological processes 18 terms
N-acetylgalactosamine-6-phosphate deacetylase activity (GO:0047419)N-acetylglucosamine catabolic process (GO:0006046)N-acetylglucosamine metabolic process (GO:0006044)N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448)N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448)N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448)N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448)N-acetylglucosamine-6-phosphate deacetylase activity (GO:0008448)N-acetylneuraminate catabolic process (GO:0019262)N-acetylneuraminate catabolic process (GO:0019262)UDP-N-acetylglucosamine biosynthetic process (GO:0006048)cytosol (GO:0005829)hydrolase activity (GO:0016787)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)negative regulation of UDP-N-acetylglucosamine biosynthetic process (GO:0106279)negative regulation of UDP-N-acetylglucosamine biosynthetic process (GO:0106279)nucleus (GO:0005634)protein binding (GO:0005515)
Expression (TPM)
AMDHD2 — as a Regulated Gene

TFs regulating AMDHD2 0 TFs

Transcription factors with Perturb-seq knockdown data for AMDHD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMDHD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to AMDHD2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMDHD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:2,223,095–2,224,285 296.9 kb Distal (>10kb) Multiome 918
chr16:2,251,044–2,252,460 268.7 kb Distal (>10kb) Multiome 996
chr16:2,267,625–2,269,111 252.1 kb Distal (>10kb) Multiome 1044
chr16:2,339,631–2,342,283 179.5 kb Distal (>10kb) Multiome 1129
chr16:2,428,282–2,429,948 91.1 kb Distal (>10kb) Multiome 827
chr16:2,459,524–2,460,612 60.3 kb Distal (>10kb) Multiome 670
chr16:2,467,565–2,468,324 52.5 kb Distal (>10kb) Multiome 450
chr16:2,470,913–2,472,223 49.1 kb Distal (>10kb) Multiome 427
chr16:2,473,455–2,476,127 45.2 kb Distal (>10kb) Multiome 719
chr16:2,501,124–2,501,877 18.9 kb Distal (>10kb) Multiome 471
chr16:2,513,006–2,514,809 6.6 kb Proximal (<10kb) Multiome 818
chr16:2,520,064–2,520,618 15 bp At TSS Multiome 624
chr16:2,531,456–2,533,080 11.8 kb Distal (>10kb) Multiome 883
chr16:2,537,433–2,538,433 17.5 kb Distal (>10kb) Multiome 498
chr16:2,603,176–2,603,939 83.0 kb Distal (>10kb) Multiome 1066
chr16:2,673,059–2,673,910 153.1 kb Distal (>10kb) Multiome 471
chr16:2,682,205–2,683,006 162.1 kb Distal (>10kb) Multiome 1003
chr16:2,720,741–2,721,896 200.9 kb Distal (>10kb) Multiome 758
chr16:2,751,637–2,753,398 232.2 kb Distal (>10kb) Multiome 1074
chr16:2,776,766–2,778,256 257.0 kb Distal (>10kb) Multiome 828

Genome Browser

Genomic view of the AMDHD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:2,213,095 – 2,788,256
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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