Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosomal transport. Predicted to act upstream of or within protein localization. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ALS2CL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALS2CL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALS2CL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:46,417,905–46,418,429 | 275.5 kb | Distal (>10kb) Multiome | 24 | |
| chr3:46,488,743–46,489,332 | 204.7 kb | Distal (>10kb) Multiome | 616 | |
| chr3:46,565,618–46,566,648 | 127.4 kb | Distal (>10kb) Multiome | 471 | |
| chr3:46,571,510–46,572,202 | 121.8 kb | Distal (>10kb) Multiome | 22 | |
| chr3:46,573,613–46,576,275 | 119.3 kb | Distal (>10kb) Multiome | 387 | |
| chr3:46,576,781–46,577,328 | 116.5 kb | Distal (>10kb) Multiome | 158 | |
| chr3:46,629,617–46,630,264 | 63.6 kb | Distal (>10kb) Multiome | 464 | |
| chr3:46,692,995–46,694,167 | 3 bp | At TSS Multiome | 390 | |
| chr3:46,695,090–46,695,483 | 1.4 kb | Proximal (<10kb) | 106 | |
| chr3:46,704,956–46,705,522 | 11.6 kb | Distal (>10kb) Multiome | 281 | |
| chr3:46,811,739–46,812,895 | 118.9 kb | Distal (>10kb) Multiome | 322 | |
| chr3:46,829,727–46,830,265 | 136.3 kb | Distal (>10kb) Multiome | 58 | |
| chr3:46,845,393–46,846,375 | 152.4 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr3:46,881,541–46,883,129 | 188.1 kb | Distal (>10kb) Multiome | 257 | |
| chr3:46,892,261–46,893,159 | 199.0 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr3:46,909,425–46,910,035 | 216.1 kb | Distal (>10kb) Multiome HiCAR | 394 | |
| chr3:46,948,015–46,948,666 | 254.7 kb | Distal (>10kb) Multiome | 529 | |
| chr3:46,976,068–46,977,401 | 283.2 kb | Distal (>10kb) Multiome | 857 | |
| chr3:46,979,117–46,980,211 | 286.0 kb | Distal (>10kb) Multiome | 777 | |
| chr3:46,987,364–46,988,143 | 294.0 kb | Distal (>10kb) Multiome | 452 |
Genomic view of the ALS2CL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.