Predicted to enable dioxygenase activity and metal ion binding activity. Involved in DNA damage response and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ALKBH7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALKBH7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALKBH7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,110,281–6,110,936 | 262.1 kb | Distal (>10kb) Multiome | 518 | |
| chr19:6,199,134–6,200,121 | 173.1 kb | Distal (>10kb) Multiome | 769 | |
| chr19:6,279,539–6,280,376 | 92.7 kb | Distal (>10kb) Multiome | 761 | |
| chr19:6,361,350–6,362,018 | 11.2 kb | Distal (>10kb) Multiome | 803 | |
| chr19:6,372,272–6,374,427 | 636 bp | At TSS Multiome | 925 | |
| chr19:6,392,902–6,394,077 | 20.7 kb | Distal (>10kb) Multiome | 767 | |
| chr19:6,423,613–6,425,899 | 52.4 kb | Distal (>10kb) Multiome | 956 | |
| chr19:6,458,960–6,460,940 | 87.6 kb | Distal (>10kb) Multiome | 859 | |
| chr19:6,463,863–6,464,838 | 91.4 kb | Distal (>10kb) Multiome | 526 | |
| chr19:6,470,903–6,471,589 | 98.5 kb | Distal (>10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 103.8 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 143.4 kb | Distal (>10kb) Multiome | 732 | |
| chr19:6,530,842–6,531,584 | 158.2 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 179.3 kb | Distal (>10kb) Multiome | 403 | |
| chr19:6,656,104–6,656,671 | 283.6 kb | Distal (>10kb) Multiome | 10 | |
| chr19:6,661,103–6,661,799 | 288.8 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the ALKBH7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.