This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Transcription factors with Perturb-seq knockdown data for ALG14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALG14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALG14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:94,819,759–94,820,829 | 252.5 kb | Distal (>10kb) Multiome | 576 | |
| chr1:94,854,217–94,855,200 | 218.3 kb | Distal (>10kb) Multiome | 530 | |
| chr1:94,925,541–94,928,082 | 145.6 kb | Distal (>10kb) Multiome | 926 | |
| chr1:95,068,829–95,069,314 | 3.6 kb | Proximal (<10kb) | 177 | |
| chr1:95,069,417–95,069,586 | 3.3 kb | Proximal (<10kb) | 124 | |
| chr1:95,072,438–95,073,470 | 25 bp | At TSS Multiome | 851 | |
| chr1:95,116,608–95,118,188 | 44.5 kb | Distal (>10kb) Multiome | 748 | |
| chr1:95,233,248–95,234,813 | 161.2 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the ALG14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.