This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ALDH1B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDH1B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDH1B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,903,405–37,904,985 | 488.5 kb | Distal (>10kb) Multiome HiCAR | 1045 | |
| chr9:37,913,669–37,914,191 | 478.8 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr9:37,922,396–37,923,788 | 469.4 kb | Distal (>10kb) Multiome HiCAR | 162 | |
| chr9:38,066,700–38,070,292 | 323.1 kb | Distal (>10kb) Multiome HiCAR | 922 | |
| chr9:38,107,683–38,108,797 | 284.5 kb | Distal (>10kb) Multiome | 259 | |
| chr9:38,154,485–38,155,231 | 237.9 kb | Distal (>10kb) Multiome | 80 | |
| chr9:38,214,046–38,215,198 | 178.0 kb | Distal (>10kb) Multiome | 249 | |
| chr9:38,226,445–38,227,547 | 165.6 kb | Distal (>10kb) Multiome | 478 | |
| chr9:38,380,130–38,381,754 | 11.7 kb | Distal (>10kb) Multiome | 696 | |
| chr9:38,392,279–38,393,206 | 39 bp | At TSS Multiome | 749 | |
| chr9:38,400,661–38,401,134 | 8.0 kb | Proximal (<10kb) | 178 | |
| chr9:38,423,581–38,424,783 | 31.6 kb | Distal (>10kb) Multiome | 342 | |
| chr9:38,427,089–38,427,935 | 34.8 kb | Distal (>10kb) Multiome | 164 | |
| chr9:38,433,915–38,434,850 | 41.8 kb | Distal (>10kb) Multiome | 31 | |
| chr9:38,619,665–38,622,690 | 228.1 kb | Distal (>10kb) Multiome | 761 | |
| chr9:38,672,308–38,672,940 | 280.0 kb | Distal (>10kb) Multiome | 541 | |
| chr9:38,689,638–38,690,086 | 297.1 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the ALDH1B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.