Enables enzyme binding activity; identical protein binding activity; and protein-macromolecule adaptor activity. Involved in proteasome localization and protein import into nucleus. Acts upstream of with a positive effect on nuclear protein quality control by the ubiquitin-proteasome system. Located in nucleoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AKIRIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKIRIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKIRIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:87,407,486–87,408,928 | 294.0 kb | Distal (>10kb) Multiome | 735 | |
| chr6:87,472,409–87,473,809 | 229.2 kb | Distal (>10kb) Multiome | 913 | |
| chr6:87,483,840–87,484,329 | 218.1 kb | Distal (>10kb) Multiome | 125 | |
| chr6:87,551,523–87,552,511 | 150.4 kb | Distal (>10kb) Multiome | 64 | |
| chr6:87,589,655–87,590,489 | 112.2 kb | Distal (>10kb) Multiome | 803 | |
| chr6:87,700,848–87,703,142 | 165 bp | At TSS Multiome | 974 | |
| chr6:87,929,751–87,930,520 | 227.8 kb | Distal (>10kb) Multiome | 426 | |
| chr6:87,932,246–87,932,753 | 230.3 kb | Distal (>10kb) Multiome | 102 |
Genomic view of the AKIRIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.